Serotonergic medication interaction warning
This formula contains both St. John’s wort and 5-HTP. Both can affect serotonin pathways, and combining them with SSRIs, other antidepressants, or other serotonergic medicines can increase the risk of serious serotonin-related toxicity.
Do not use this product with an SSRI or another medicine that affects serotonin unless a clinician who knows your medication list says it is appropriate. Memorial Sloan Kettering also advises avoiding the combination of 5-HTP and St. John’s wort because both may affect serotonin levels. St. John’s wort has additional clinically important drug interactions and may reduce the effectiveness of medicines such as oral contraceptives, anticoagulants, transplant medicines, and some HIV or cancer treatments. If you take prescription or over-the-counter medicines, check with a pharmacist or clinician before use. Do not stop a prescribed medicine on your own.
Memorial Sloan Kettering — St. John’s Wort